Described herein is a hand-held catheter force control device comprising: an elongate base sized to be hand-held, the base defining a longitudinal axis between first and second opposing longitudinal ends; a linear actuator mounted to the base to provide linear motion substantially parallel to the longitudinal axis of the base; a sheath clamp coupled to the base, the sheath clamp sized to fixedly capture a sheath handle; a catheter clamp coupled to the linear actuator, the catheter clamp sized to fixedly capture a catheter; and the catheter clamp aligned to be substantially co-axial with the sheath clamp. Systems and methods incorporating the catheter force control device are also described.