Paula A. Faria-Waziry,Luigi X. Cubeddu,Ana Maria Castejon
申请号：
US13988768
公开号：
US20130302284A1
申请日:
2011.11.22
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Simvastatin is used to modulate VSV infection at the level of viral replication. Both lipid-lowering and pleiotropic cellular effects of simvastatin are exploited in the modulation. Simvastatin upregulates the expression of Rae1 and Nup98, therefore altering normal cellular mRNA distribution and reverting VSVs mRNA export block. Furthermore, simvastatin causes redistribution of Flotillin-1, which affects VSV replication/budding. Simvastatin is further used as a neoadjuvant for the selective modulatory control of live VSV oncolytic therapy.
