Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3 and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.本發明化合物，譬如式Ia、Ib、Ic或Id化合物與其藥學上可接受之鹽、異構物及前體藥物，其可作為肝臟X受體活性之調節劑使用，其中R1,R2,R21,R3及G均定義於本文中。亦揭示含有該化合物之醫藥組合物，及使用該化合物之方法。
