A system for the treatment of targets under the skin of a patient comprising: a laser device for emitting a first series of laser pulses towards an area of the skin of a patient, where a target which must be reached by said laser pulses is located under said skin； a cooling system of said area of the skin by means of a cooling fluid； a first measurement sensor of a first temperature of said area of skin； a second measurement sensor of the temperature of said cooling fluid； said computer which receives the signals from said first and second temperature measurement sensor； said computer controls said laser device that emits a first series of laser pulses having predetermined power, duration and spacing； said temperature measurement sensor measures the temperature of said area of skin, following said first series of laser pulses； said computer calculates the predicted temperature reached of said area of the skin following the emission of a second series of pulses having said predetermined power, duration and spacing.
