The present invention provides methods for increasing secretion of dopamine and other neurotransmitters and treating or reducing the incidence of diseases involving decreased secretion of dopamine and other neurotransmitters, e.g. Parkinsons disease, comprising administering to the subject a uridine or a source thereof, and compositions for treating or reducing an incidence of Parkinsons disease, comprising a uridine, a uridine monophosphate, or a source thereof.