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Genetically engineered murine animal as a model for Primary Membraneous Nephropathy
专利权人:
发明人:
申请号:
EP14169619.5
公开号:
EP2946663A1
申请日:
2014.05.23
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
The invention relates to a genetically engineered murine animal, in particular a gene knockin mouse, as animal model for human disease. The technical problem to be solved is to provide a suitable means for assisting research for the causes and the development of and possible therapies and/or therapeutic agents for primary membranous nephropathy. For this purpose, the invention provides, in a first aspect, a genetically engineered murine animal, having expressibly integrated into the genome of all its germ cells and somatic cells a nucleic acid sequence coding for a fusion protein comprising the extracellular domains of the human phospholipase A2 receptor (hPLA2R), an ER targeting signal peptide and a membrane anchoring domain.
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