KARTINI BINTI NOORSAL,SUHAIDA BINTI MAT GHANI,DARMAWATI BINTI MOHAMAD YUNUS,MOHD. SALIHUDDIN BIN WAN MOHAMED,AHMAD FUAD BIN YAHYA
申请号：
MYPI 20080063
公开号：
MY147008A
申请日:
2008.01.14
申请国别(地区):
MY
年份:
2012
代理人:
摘要：
THE PRESENT INVENTION DESCRIBES A METHOD FOR PREPARING A CONTROLLED RELEASE OF ANTICANCER DRUG VEHICLE COMPRISING BIODEGRADABLE COPOLYMER POLY(LACTIDE-CO-GLYCOLIDE) (PLGA) AND AN ANTICANCER DRUG USING MELTING COMPRESSION WHEREBY THE STEPS OF SAID METHOD INCLUDE: A. PULVERIZING SAID BIODEGRADABLE COPOLYMER POLY(LACTIDE-CO-GLYCOLIDE) (PLGA) TO FINE POWDER OF APPROXIMATELY 5 MICRON B. ADDING SAID ANTICANCER DRUG TO SAID PLGA POWDER AND MIXING THE COMPOUND TO PRODUCE A HOMOGENOUS MIXTURE C. SUBJECTING SAID HOMOGENOUS MIXTURE TO HOT PRESS IN A DESIRABLE MOULD AT A TEMPERATURE OF 140°C AND A PRESSURE OF 20 MPA [200 BAR] TO PRODUCE A CONTROLLED RELEASE ANTICANCER DISC D. QUENCHING THE PRODUCED DISC IN COLD WATER, PREFERABLY ICED WATER. PREFERABLY, SAID ANTICANCER DRUG IS CIS PLATIN.
