VERDINE, GREGORY, L.,MEENA, MEENA,IWANOTO, NAOKI,BUTLER, DAVID, CHARLES DONNELL
申请号：
EP12814522
公开号：
EP2734208A4
申请日:
2012.07.13
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Described herein are thiosulfonate reagents of Structure IIa useful for the synthesis of phosphorothiotriesters from H-phosphonates in a stereospecific fashion. wherein, X is alkyl, cycloalkyl, or heteroaryl； R is R 1 -R 2 ； R 1 is selected from -S-alkenylene-, -S-alkylene-, -S-alkylene-aryl-alkylene-, -S-CO-aryl-alkylene-, and -S-CO-alkylene-aryl-alkylene-； and R 2 is selected from heterocyclo-alkylene-S-, heterocyclo-alkenylene-S-,aminoalkyl-S-, and (alkyl) 4 N-alkylene-S-.
