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COATINGS RELEASING MEDICINES FOR MEDICAL DEVICES
专利权人:
ЛУТОНИКС; ИНК. (US)
发明人:
ВАН Лисяо (US)
申请号:
RU2012145021/15
公开号:
RU2012145021A
申请日:
2010.03.25
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A medical device for delivering a therapeutic agent to a tissue, containing on its outer surface a coating layer that includes a therapeutic agent, an antioxidant and an additive, the antioxidant being selected from at least one of butylated hydroxytoluene and butylated hydroxyanisole, containing a hydrophilic component and a component having chemical affinity for a drug, wherein the component having an affinity for a drug is at least one of a hydrophobic component, a component whose chemical affinity for a therapeutic agent is determined by hydrogen bonds, and / or a component whose chemical affinity for a therapeutic agent is determined by Van- der Waals; wherein the additive is water-soluble, the additive being at least one of a surfactant and a chemical compound that contains one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups. A medical device according to claim 1, wherein the chemical compound is selected from: amino alcohols, oxycarboxylic acid, ester, amides, ethers, anhydrides, hydroxyketone, hydroxylactone, hydroxyesters, sugar phosphate, sugar sulfate, diethyl ether, ethyl glycols, amino acids, peptides, proteins, sorbitan, glycerol, polyhydric alcohol, phosphates, sulfates, organic acids, salts, vitamins, as well as combinations of amino alcohols and organic acids, and these compounds with substituted molecules. 3. A medical device according to claim 1, in which the surfactant is selected from: ionic, �1. Медицинское устройство для доставки лечебного средства к ткани, содержащее на своей внешней поверхности слой покрытия, который включает лечебное средство, антиоксидант и добавку,причем антиоксидант выбран по меньшей мере из одрого из бутилированного гидрокситолуола и бутилированного гидроксианизола,содержащую гидрофильный компонент и компонент, имеющий химическое сродство к лекарственному средству, причем компонент, имеющий сродство к лекарственному средству является по меньшей мере одним из гидрофобного компонента, компонен
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