ONO KOJI,MATSUMOTO SHIGEMITSU,KATOH TAISUKE,MIWA KAZUHIRO,HASUOKA ATSUSHI,IMAMURA SHINICHI,TOMINARI YUSUKE
申请号:
ARP120102865
公开号:
AR087466A1
申请日:
2012.08.06
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
This provides a compound that has a higher activity as a Modulator of err - and Utility as an agent for the Prevention or treatment of diseases associated with err - such as malignant tumors of various types.Claim 1: a compound represented by the formula (1) where a is a cyclic group which has optionally substituents; is a Link, - O -, co -, - S -, - and - SO2 -, -, - or - nrl1 nrl1 co; lb is a link or a group alquileno C1 - 3 which has optionally substituents; LK is a Link. - CO -, - or - CO -, co - nrl2 - SO2 -, - or - nrl2 - SO2 -; RL1, RL2 are each, independently,A Hydrogen Atom, a group which has optionally Hydrocarbon substituents, a group which has optionally Heterocyclic substituents, a group that has a Hydroxy Substituent Optionally,It has an amino group or an acyl Group substituents; G ring is a saturated Heterocycles 4 to 10 members containing a nitrogen Atom as a constituent atom of the ring, which is optionally in Bridge and optionally have substituents; and E is a group rep Resentado BY FORMULA (2) or (3) where X is - S -, - or - or - NRX -; and R1, R2, R3 and RX are each,Independently, a hydrogen Atom, a Hydrocarbon group which has optionally optionally Heterocyclic substituents, a group that has a Hydroxy Substituent optionally has a Substituent Group, an amino group or a group which has optionally substituents ACI The R1 and R2 or optionally in combination form, along with the adjacent nitrogen Atom,A heterocycle containing nitrogen which has optionally substituents R1 and R3 or optionally in combination form, along with the adjacent nitrogen ATOMS, a nitrogen heterocycle containing 5 to 7 members has optionally substituents; or one of its Salts.La presente proporciona un compuesto que tiene una actividad superior como un modulador de ERR-a y de utilidad como un agente para la prevención o el tratamiento de enfermedades asociadas con ERR-a tales como tumores malignos de diversos tipos.Reivindicación 1: Un compuesto representado por la fórmula (1) en