The present invention relates to a thrombectomy system comprising an elongate shaft defining a high pressure lumen configured to couple to a fluid source and a low pressure lumen configured to couple to a vacuum source, the high pressure lumen terminating near the distal end of the low pressure lumen, wherein the high pressure lumen terminates in an distal opening directed generally between perpendicular to the axis of the low pressure lumen and axially within the low pressure lumen in the proximal direction so as to provide a fluid jet that at least partially traverses the low pressure lumen.
