James Murtagh;Gonto Johns;Bagavathikanun C. Thanoo
发明人:
Bagavathikanun C. Thanoo,James Murtagh,Gonto Johns
申请号：
US10894956
公开号：
US08343513B2
申请日:
2004.07.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Polymer and drug containing compositions and method of preparing such compositions are disclosed. The dispersed phase formulation has a polymer, a pharmaceutically or biologically active agent and a small fraction of low pKa acid additive. Stable, filter sterilizable, non-gelling solutions containing GnRH analogues at least at levels typically used in sustained release formulations and a method of increasing solubility of a high level of a GnRH analogue or a freeze-dried antagonist of GnRH in a polymer containing solution are also disclosed. The amount of the acid additive in the polymer solution is such that it is sufficient to increase the solubility of the high level of the GnRH analogue in the polymer solution without affecting the release characteristics of the microspheres prepared therefrom.
