As for this invention, from the fact that it possesses gluco kinase activated operation, the complication of diabetes and diabetes or remedy of obesity and/or in prevention useful formula (i)< Conversion 1 >[In formula, R to show the karubamoiru basis and the like, R to show the low-grade alkyl group and the like, X and X to show everything CH, or or, X or X each one to show the nitrogen atom, at the same time, remaining one CH showing,< Conversion 2 >So as for the basis which is displayed, the pyridinyl group, the pyrazinyl basis, the pyrazolyl basis, the thiadiazolyl basis and the triazoryl basis, from the group which consists of the isoxazolyl group, and the thiazolyl basis showing the basis which is chosen,k shows 0 or 1] with the chemical compound which is displayed or regards the salt which that pharmacy is allowed.< Choice figure >It is not本発明は、グルコキナーゼ活性化作用を有することから、糖尿病、糖尿病の合併症若しくは肥満の治療及び/又は予防に有用な式(I)【化1】[式中、R1はカルバモイル基等を示し、R2は低級アルキル基等を示し、X1及びX2は、全てCHを示すか、或いは、X1又はX2のいずれか1つが窒素原子を示し、かつ、残りの1つがCHを示し、【化2】で表される基は、ピリジニル基、ピラジニル基、ピラゾリル基、チアジアゾリル基、トリアゾリル基、イソキサゾリル基、及びチアゾリル基からなる群より選択される基を示し、kは0又は1を示す]で表される化合物又はその薬学的に許容される塩に関する。【選択図】なし
