MACDONALD, GREGOR JAMES,麦葛雷,麥葛雷,BARTOLOME-NEBREDA, JOSE MANUEL,巴特罗,巴特羅,VAN GOOL, MICHIEL LUC MARIA,范古尔,范古爾
申请号：
TW097114580
公开号：
TWI423969B
申请日:
2008.04.22
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention relates to [1-(benzyl)-piperidin-4-yl]-([1, 3, 4] thiadiazol-2-yl)-amine and [1-(benzyl)-piperidin-4-yl]-(thiazol-2-yl)-amine derivatives that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.本發明關於作為快速解離多巴胺2受體拮抗劑之[1-(苯甲基)-六氫吡啶-4-基]-([1,3,4]噻二唑-2-基)-胺及[1-(苯甲基)-六氫吡啶-4-基]-(噻唑-2-基)-胺衍生物類、這些化合物之製法、包含以這些化合物作為活性成分之藥學的組成物,這些化合物具有作為醫藥品之用途,藉由發揮一種不帶運動副作用的抗精神病之效果,供治療或預防中樞神經系統疾病,例如,精神分裂症(Schizophrenia)。
