The present invention relates to novel macrocyclic compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).本發明係關於如本文中描述及定義之新穎的通式(I)之巨環化合物,及其製備方法,其用於治療及/或預防病症,尤其過度增生性病症及/或病毒誘導之感染性疾病及/或心血管疾病之用途。本發明進一步係關於適用於製備該等通式(I)之化合物的中間化合物。