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Composition for coating comprising low-substituted cellulose ether for taste-masking and coated preparation therof
专利权人:
发明人:
申请号:
EP06253878.0
公开号:
EP1749518B1
申请日:
2006.07.25
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
Coating with a conventional water-soluble polymer cannot desirably mask an unpleasant taste because of insufficient water resistance of a coating layer. When a water-soluble base material is used, sticky or slimy feel by administration exists. On the other hand, coating with a conventional water-insoluble base material deteriorates the elution of a drug. In addition, the water-insoluble base material cannot be applied easily in an aqueous coating. The present invention has been made in order to overcome these problems. Specifically, provided are a composition for coating comprising a wet-milled product obtained by suspending low-substituted cellulose ether having a molar substitution of from 0.05 to 1.0 per anhydrous glucose unit in water and then applying a shear force to the aqueous dispersion and a coated preparation prepared using the composition for coating so as to have an unpleasant taste masked and sticky or slimy feel by administration controlled.
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