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DERIVADOS ALIFATICOS DE PROLINAMIDA.
专利权人:
ORION OPHTHALMOLOGY LLC
发明人:
Austin Chih- Yu CHEN,Thomas Jon SEIDERS,Robert GOMEZ,Renata, Marcella OBALLA,David Andrew POWELL,Jeffrey Roger ROPPE,Tao SHENG
申请号:
MX2018016102
公开号:
MX2018016102A
申请日:
2017.06.15
申请国别(地区):
MX
年份:
2019
代理人:
摘要:
This invention is directed to novel aliphatic prolinamide derivatives of Formula I, and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g., controlling, alleviating, or slowing the progression of) of age-related macular degeneration (AMD) and related diseases of the eye. These diseases include dry-AMD, wet-AMD, geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells. The invention disclosed herein is further directed to methods of prevention, slowing the progress of, and treatment of dry-AMD, wet-AMD, and geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells, comprising: administration of a therapeutically effective amount of compound of the invention. The compounds of the invention are inhibitors of HTRAl. Thus, the compounds of the invention are useful in the prevention and treatment of a wide range of diseases mediated (in whole or in part) by HTRAl. The compounds of the invention are also useful for inhibiting HTRAl protease activity in an eye or locus of an arthritis or related condition.Esta invencion se refiere a nuevos derivados alifaticos de prolinamida de formula I, (ver fórmula I) y sales, solvatos, solvatos de la sal y profarmacos de los mismos farmacéuticamente aceptables, utiles en la prevencion (por ejemplo, retrasar el inicio o reducir el riesgo de desarrollo) y tratamiento (por ejemplo, controlar, aliviar o retardar la progresion de) la degeneracion macular relacionada con la edad (AMD) y enfermedades relacionadas del ojo; estas enfermedades incluyen AMD seca, AMD humeda, atrofia geografica, retinopatia diabetica, retinopatia del prematuro, vasculopatia coroidea polipoidea y degeneracion de las celulas re
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