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Salt form of tyrosine kinase inhibitor
专利权人:
发明人:
Feng Tang,Qiu Jin,Wei Li,Tian Zhu,Yang Hu,Feng Shao
申请号:
US14023486
公开号:
US09018242B2
申请日:
2013.09.11
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Provided are acid addition salts of (Z)—N-[2-(diethylamino)ethyl]-2-methyl-7-(1,2 -dihydro-5-fluoro-2-oxo-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indol-3-carboxamide, wherein the salt comprising at least one of a number of salts including L-malate, hydrochloride, phosphate, L-tartrate, benzenesulfonate, sulfate, methanesulfonate, succinate, citrate, fumarate, p-toluenesulfonate, hydrobromate, L-mandelate, lactate, acetate or maleate salt. Also provided is a pharmaceutical composition comprising the salt compounds, and a method of treatment by administering a therapeutically effective amount of the salt compounds as preparation of medicaments.
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