Shubh Sharma,Leonardus H.T. Van Der Ploeg,Bart Henderson
申请号：
US14775911
公开号：
US20160022764A1
申请日:
2014.03.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to an ionic complex comprising a cationic polypeptide and an anionic excipient selected from: a PEG-carboxylic acid； a fatty acid having 10 or more carbon atoms； an anionic phospholipid； and a combination thereof. The invention also relates to a pharmaceutical composition comprising the ionic complex of the invention and a pharmaceutically acceptable carrier. The cationic polypeptide of the ionic complex has pharmacological activity and the complex can provide a more desirable pharmacokinetic profile for the cationic polypeptide of the complex as compared to the cationic polypeptide alone following administration. As such, the invention also relates to the use of the ionic complex and pharmaceutical composition comprising same to treat a subject suffering from a disease or disorder that is responsive to the cationic polypeptide of the ionic complex.
