KWON SE CHANG,PARK SUNG HEE,LIM SE YOUNG,SHIN RYOUNG AE,CHOI IN YOUNG
申请号：
NZ62882813
公开号：
NZ628828A
申请日:
2013.03.08
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The disclosure relates to a pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease comprising an insulinotropic peptide drug conjugate prepared by covalently linking an insulinotropic peptide and an immunoglobulin Fc region via a non-peptidyl polymer as an active ingredient, wherein the insulinotropic peptide is selected from the group consisting of exendin-4 or exendin-4 derivatives. The non-peptidyl polymer is selected from the group consisting of polyethylene glycol, polypropylene glycol, copolymers of ethylene glycol-propylene glycol, polyoxyethylated polyols, polyvinyl alcohol, polysaccharides, dextran, polyvinyl ethyl ether, biodegradable polymers, lipid polymers, chitins, hyaluronic acid, and combinations thereof.
