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METHOD FOR INHIBITING ACTIVITY AND/OR EXPRESSION OF MATRIX METALLOPROTEINASE, INHIBITING PHOSPHORYLATION OF MITOGEN-ACTIVATED PROTEIN KINASE, AND/OR PROMOTING EXPRESSION OF COLLAGEN USING TORMENTIC ACID
专利权人:
Sze-Ying Chen;Wen-Chuan Lin;Hui-Ya Ho;Jin-Bin Wu
发明人:
Jin-Bin Wu,Wen-Chuan Lin,Hui-Ya Ho,Sze-Ying Chen
申请号:
US12955336
公开号:
US20120059059A1
申请日:
2010.11.29
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A method for inhibiting the activity of matrix metalloproteinase (MMP), inhibiting the expression of matrix metalloproteinase, inhibiting the phosphorylation of mitogen-activated protein kinase (MAPK), and/or promoting the expression of collagen in a mammal is provided. The method comprises administrating to the mammal an effective amount of an active component selected from a group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable ester of the compound, and combinations thereof:
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