用於治療蛋白質病變（ＰＲＯＴＥＩＮＯＰＡＴＨＩＥＳ）的組成物及方法农业专利-农业专业知识服务系统

发明人:: SARDI, SERGIO PABLO,萨瑞迪　索吉欧,薩瑞迪　索吉歐,SHIHABUDDIN, LAMYA,萨哈布狄恩　兰亚,薩哈布狄恩　蘭亞,CHENG, SENG H.,郑承兴,鄭承興,萨瑞迪索吉欧,薩瑞迪索吉歐,萨哈布狄恩兰亚,薩哈布狄恩蘭亞

摘要：: This disclosure relates to methods for improving neural function in a mammal with a proteinopathy comprising administering a therapeutically effective amount of an agent that increases glucocerebrosidase activity in the mammal. Also disclosed are methods for reducing toxic lipids, reducing α-synuclein, and/or inhibiting the accumulation of protein aggregates in a mammal with a proteinopathy comprising administering a therapeutically effective amount of an agent that increases glucocerebrosidase activity.本發明係有關於罹患蛋白質病變哺乳動物中，增進神經功能之方法，該方法包括投予有效治療量之增加哺乳動物葡萄糖腦苷脂酶活性之製劑。本發明亦揭示於罹患蛋白質病變哺乳動物中，降低毒性脂質、降低α-突觸核蛋白、及/或抑制蛋白質聚集體蓄積之方法，該方法包括投予有效治療量之增加葡萄糖腦苷脂酶活性之製劑。