An artificial antibody library with a super-repertory (1011 or more) is constructed by: using a cDNA library as a template, amplifying a fragment containing the CDR1 and CDR2s regions of the VH or VL region of immunoglobulin gene and a fragment containing the CDR3 region each by the PCR method integrating the VH library and the VL library, which are little contaminated with unexpressionable repertory and have high safety, into an non-expression vector transferring it into a host and then shuffling the VH region in the VH library with the VL region in the VL library.
