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LIPOSOMALE NANOKONSTRUKTE UND VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DAVON
专利权人:
发明人:
申请号:
EP16800711.0
公开号:
EP3302436A1
申请日:
2016.05.26
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
Provided herein is a liposome comprising: a) a conjugate comprising a lysophospholipid and a photosensitizer b) a first derivatized phospholipid comprising a first phospholipid and a strained cyclooctyne moiety c) a second derivatized phospholipid comprising a second phospholipid and a polyethylene glycol polymer and d) a cationic or anionic lipid. Also provided herein is a liposome comprising: a) a conjugate comprising a lysophospholipid and a photosensitizer b) a first derivatized phospholipid comprising a first phospholipid and a targeting moiety c) a second derivatized phospholipid comprising a second phospholipid and a polyethylene glycol polymer and d) a cationic or anionic lipid. The liposomes provided herein can be used, for example, in the treatment of cancer or in the imaging of cancer tumors.
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