The problem to be solved by the present invention isto provide a safe and efficacious therapeutic agent fordermatitis which is not only safe and efficacious forpatients with dermatitis, in particular atopic dermatitis,but also significantly effective for severe cases that arejudged to be intractable by conventional externalpreparations, and which is also safely applicable toaffected areas such as the face and neck, as well as tosubjects with sensitive skin, such as infants and females.Furthermore, the invention aims to provide an externalpreparation that is efficacious as skin care cosmeticshaving effects to improve elasticity and wrinkles of theskin, moisturizing effects, and hair-growth effects.The means for solving the problem is a skinexternal-preparation composition, in particular, a therapeutic agentfor dermatitis or a skin texture-improving agent, havingC-type natriuretic peptide (CNP) or B-type natriureticpeptide (BNP) as the active ingredient.
