Shi Shuai,Antochshuk Valentyn,Rizzo Joseph,Kaarsholm Niels C.
申请号：
US201815966585
公开号：
US2018318426(A1)
申请日:
2018.04.30
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
Disclosed is a pharmaceutical formulation comprising an insulin or insulin analog molecule covalently attached to at least one branched linker having a first arm and second arm, wherein the first arm is linked to a first ligand that includes a first saccharide and the second arm is linked to a second ligand that includes a second saccharide and wherein the first saccharide is fucose. The formulation is suitable for subcutaneous administration and provides a basal pharmacodynamic profile for the insulin oligosaccharide conjugate.
