Since ancient times people have been using natural resources for photo-protection purposes. One such highly recognized natural agent is Pomegranate seed oil, considered as wonder oil owing to the presence of several beneficial phyto-constituents. The aim of this invention is to establish the photo-protective potential of Pomegranate seed oil through various in-vitro and biochemical studies along with the formulation of QbD based nanoemulsion, an efficient topical delivery system for the oil. Photo-protective potential of the oil was estimated by determining in-vitro antioxidant and anti-inflammatory activity, total phenolic content, antielastase, antihyaluronidase and anticollagenase activities of the oil. Ultrasonication method was used to formulate nanoemulsions. The optimized nanoemulsion was formulated into a gel base and further release studies were carried out. From the findings it was found that Pomegranate seed oil possess a potential photo-protective ability. Nanoemulsions proved to be a promising carrier for the topical delivery of the oil.
