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PIPERAZINO[1,2-A]INDOL-1-ONES AND [1,4]DIAZEPINO[1,2-A]INDOL-1-ONE
专利权人:
发明人:
申请号:
HK15107077.4
公开号:
HK1206355B
申请日:
2015.07.24
申请国别(地区):
HK
年份:
2018
代理人:
摘要:
The present invention relates to compounds of general formula (I), wherein R1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkoxy substituted by halogen or cyano R2 is hydrogen, lower alkyl or lower alkyl substituted by halogen R3 is phenyl, benzo[1,3]dioxolyl, 2,3-dihydro-benzofuran-5-yl or a 5- and 6-membered heteroaryl, wherein phenyl and the 5- and 6-membered heteroaryl groups may be substituted by one or more substituents, selected from cyano, nitro, amino and lower di-alkylamino, lower alkyl sulfonyl, lower alkoxy, lower alkoxy substituted by halogen, halogen, lower alkyl, lower alkyl substituted by halogen or lower alkyl substituted by hydroxyl X is -CH(lower alkyl)-, -CH2-, -CH2CH2- or –CH(lower alkyl)CH2- R is hydrogen or lower alkyl n is 1 or 2 or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds may be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinsons disease, dementia, Alzheimers disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntingtons disease, stroke, radiation therapy, chronic stress, abuse of neuro-active drugs, such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.La présente invention concerne des composés de formule générale (I), dans laquelle R1 représente hydrogène, halogène, alkyle inférieur, alcoxy inférieur, alcoxy inférieur substitué par halogène ou cyano R2 représente hydrogène, alkyle inférieur ou alkyle inférieur substitué par halogène R3 représente phényle, benzo[1,3]dioxolyle, 2,3-dihydro-benzofuran-5
来源网站:
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