MACDONALD GREGOR JAMES,TRABANCO SUÁREZ Andrés Avelino,CONDE CEIDE SUSANA,TRESADERN GARY JOHN,BARTOLOMÉ NEBREDA José Manuel,PASTOR FERNÁNDEZ JOAQUIN
申请号：
IN1765/MUMNP/2012
公开号：
IN2012MN01765A
申请日:
2012.07.17
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention relates to novel bicyclic thiazoles of formula (I) which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ("mGluR5") and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds to processes for preparing such compounds and compositions and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.
