BENEDICT, JAMES J.,BREWSTER, GREG ALLEN,FREEMAN, DONALD BARCLAY
申请号：
CA2633551
公开号：
CA2633551C
申请日:
2006.12.15
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
A firm but pliable medical device for use as a bone graft substitute or bonegraft extender retains its shape without the requirement of a containmentdevice, such as a syringe. Because the device is solid, it is easy to locateor position in-vivo and, in the moist environment of the body, it will holdits shape well, for an extended time. Because the lyophilized pliable medicaldevice is porous, it adsorbs blood and other beneficial cells containing bodyfluids, such as bone marrow, contributing to its superior bone repair efficacyin comparison to an analogous putty that has not been lyophilized. In additionthese lyophilized pliable medical devices are easier to terminally steamsterilize than the analogous putty because there is no moisture present toboil and "blow-out" of the containment device (syringe). The glycerin that ispresent in the formulation lends pliability but has a low vapor pressure.
