As for this invention, until (1) tamusuroshin hydrochloride (a), the crystallite cellulose (b) and the water, (a) the component and (b) the water permeates uniformly in the blend of the component, the process which it mixes agitates, (2) is obtained with process production method of the globose particulate which includes the process which dries granulation ones which (1) the blend which, making use of the agitation granulating machine which sets to peripheral speed 5.5 - 9.0m/s process, and (3) granulation it does are obtained with process (2), contains tamusuroshin hydrochloride is offered. In addition, as for this invention, the collapse lock inside the buccal cavity which contains the coating particulate, and the said coating particulate which are obtained by administering coating to the globose particulate and the said globose particulate which can by the above-mentioned method is offered.本発明は、(1)タムスロシン塩酸塩(a)、微結晶セルロース(b)及び水を、(a)成分及び(b)成分の混合物中に水が均一に浸透するまで、混合撹拌する工程、(2)工程(1)で得られた混合物を、周速5.5~9.0m/sに設定した撹拌造粒機を用いて造粒する工程、並びに(3)工程(2)で得られた造粒物を乾燥する工程を含む、タムスロシン塩酸塩を含有する球形微粒子の製造方法を提供する。また、本発明は、上記方法によって得られる球形微粒子、該球形微粒子にコーティングを施すことにより得られる被覆微粒子、及び該被覆微粒子を含有する口腔内崩壊錠を提供する。