The present invention provides methods and a BFS/FFS system for delivering either one or more substances within at least one body cavity, characterized by a vial comprising Vsub [ml] of said substances； said vail selected from a pierceable container, a blow-fill-seal and a form-fill-seal, having fluid inlet and a fluid discharging outlet of diameter D [mm], configured for placement in proximity to said body cavity； said fluid inlet configured by means of size and shape to interface in a sealable manner a puncturing member, configured to, upon coupling to said fluid inlet, piercing the same, thereby providing said substances in a fluid communication, via a valve, with a chamber configured to accept pressurized fluid at volume VPF [ml] and pressure PPF [barg]； said valve is commutable from an CLOSE to an OPEN CONFIGURATION within a short period of time, <；500 milliseconds (dT)； at said OPEN CONFIGURATION, said pressurized fluid flows from said chamber, via said fluid inlet, entrains said substances by one of the followings: (i) one portion mVPF/n, n=portion (%, v/v), m=1, (ii) a plurality of portions, mVPF/n, m≥；2, or (iii) the whole VPF, n,m=1 erupts via said fluid discharging outlet to within said body cavity.
