"a compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent"
BRAZOZKA KRZYSZTOF,CZARDYBON WOJCIECH,SABINIARZ ALEKSANDRA,MILLIK MARIUSZ,WINDAK RENATA,ZAREBSKI ADRIAN,BEUZEN NICOLAS
申请号：
IN4014/DELNP/2012
公开号：
IN2012DN04014A
申请日:
2012.05.07
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The subject of the inventions are a compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine and tyrosine kinases and a serine/threonine and tyrosine kinases modulating agent. The present invention relates to novel small-molecule compounds with kinase inhibitory activity, having superior properties as pharmaceutical agents, production method thereof and uses thereof. In particular, this invention relates to new derivatives of tetrahalogenated benzimidazole with serine/threonine and tyrosine kinases inhibitory properties, preferably selected from the group of PIM, HIPK, DYRK, CLK, CDK, FLT, PKG, Haspin, MER, TAO, MNK, TRK kinases which exhibit superior pharmacological actions, and can be useful for the treatment of disease conditions, especially cancers depending on serine/threonine and tyrosine kinases, such as but not limited to leukemias and solid tumors.
