A method for performing registration of multispectral retinal images. Corresponding cross-over points and bifurcation points of blood vessel in an eye are identified in a fixed image and in an offset image. The relative displacement of each point, between the images, is calculated. Based on these relative displacements, the offset of each pixel in the offset image is interpolated and the offset image is transformed into a corrected (distorted) image. Such an image can be used to assess the health of the eye. Further, a fixed image and a offset image of an eye are divided in a tile pattern. The relative displacement of each tile of the offset image with respect to the corresponding tile in the fixed image is calculated. An offset for each tile is calculated and the offset image is corrected as a function of those offsets.
