Tykocinski, Mark L.,Shani, Noam,Gozlan, Yosi,Dranitzki Elhalel, Michal,Bremer, Edwin,Kaminsky, Ido
申请号：
AU2018205888
公开号：
AU2018205888A1
申请日:
2018.01.04
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
PD1-41BBL fusion proteins are provided. Accordingly, there is provided a PD1-41BBL fusion protein comprising a single amino acid linker between the PD1 and the 41BBL. Also there is provided a PD1-41BBL fusion protein, wherein the PD1 amino acid is 123-166 amino acids in length and/or wherein the PD1 amino acid sequence comprises SEQ ID NO: 2 and/or wherein the fusion protein is in a form of at least a homo-trimer. Also provided are polynucleotides and nucleic acid constructs encoding the PD1-41BBL fusion protein, host-cells expressing the PD1-41BBL fusion protein and methods of use thereof.
