Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
发明人:
IACOANGELI, Tommaso,CHIAVARINI, Mario,FAZIO, Antonello,MARCHETTI, Marcello,CIOTTOLI, Giovanni Battista
申请号：
ES12700288
公开号：
ES2605425T3
申请日:
2012.01.17
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Method of preparing metaxalone having the following structural formula (I): ** Formula ** comprising the triglycidyl isocyanurate (TGIC) reaction of formula (III) ** Formula ** with m-xylenol of formula (V) ** Formula ** characterized in that said reaction is carried out in a solvent mixture comprising a first solvent selected from the group consisting of N-methylpyrrolidone, dimethylformamide, dimethyl sulfoxide, hexamethylphosphoramide, dimethylacetamide and acetonitrile and a second solvent selected from the group consisting of cyclohexane, heptane, benzene, toluene, xylene, mesitylene, naphthalene, chlorobenzene, chloroxylene, chloroform, propyl ether, isopropyl ether, butyl ether, pentylether, benzylethyl ether, tetrahydrofuran (THF), 2-methyl tetrahydrofuran, acetone , methylbutyl ketone, methyl isobutyl ketone, 2-pentanone, cyclopentanone and 2- heptanone, said solvent mixture comprising from 5 to 40% by weight of said first solvent and from 95 to 60% by weight of said second solvent, add the TGIC at a temperature between 30 ° C and 50 ° C and after adding the TGIC raise the temperature of the reaction solution to a value between 80 ° C and 180 ° C in a period between 120 and 180 minutes at a rate of increase not exceeding 1.25 ° C per minute.Procedimiento de preparación de metaxalona que presenta la fórmula estructural (I) siguiente:**Fórmula** que comprende la reacción de isocianurato de triglicidilo (TGIC) de fórmula (III)**Fórmula** con m-xilenol de fórmula (V)**Fórmula** caracterizado por que dicha reacción se lleva a cabo en una mezcla de disolventes que comprende un primer disolvente seleccionado de entre el grupo que consiste en N-metilpirrolidona, dimetilformamida, dimetilsulfóxido, hexametilfosforamida, dimetilacetamida y acetonitrilo y un segundo disolvente seleccionado de entre el grupo que consiste en ciclohexano, heptano, benceno, tolueno, xileno, mesitileno, naftaleno, clorobenceno, cloroxileno, cloroformo, propiléter, isopropiléter, butiléter,
