KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;한국생명공학연구원;주식회사 중앙백신연구소;CHOONG ANG VACCINE LAB.
发明人:
AHN, JUNG OH,안정오,HONG, MIN HEE,홍민희,LEE, HONG WEON,이홍원,LEE, EUN GYO,이은교,KIM, CHUN SUG,김천석,LEE, HYEOK WON,이혁원,LEE, JOO HWAN,이주환,JUNG, JOON KI,정준기,YOON, IN JOONG,윤인중,YOO, SUNG SIK,유성식,김연구,AHN, JUNG OHKR,HONG, MIN HEEKR,LEE, HONG WEONKR,LEE, EUN GYOKR,KIM, CHUN SUGKR,LEE, HYEOK WONKR,LEE, JOO HWANKR,JUNG, JOON KIKR,YOON, IN JOONGKR,YOO, SUNG SIKKR
申请号：
KR1020120156944
公开号：
KR1020140087289A
申请日:
2012.12.28
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention relates to a method for producing a vaccine against swine erysipelas diseases through the immobilization of antigenic proteins. The method comprising the steps of: producing a fused protein connected with a cellulose binding domain (CBD) protein and a surface protective antigen A (SpaA) which is an antigenic protein derived from Erysipellothrix rhusiophathiae； and fixing the fused protein to a cellulose matrix.본 발명은 돈단독균(Erysipellothrix rhusiophathiae) 유래 항원성 단백질 SpaA(surface protective antigen A) 및 셀룰로오스 바인딩 도메인(CBD) 단백질이 연결된 융합 단백질을 제조하고； 상기 융합 단백질을 셀룰로오스 매트릭스에 고정화하는； 단계를 포함하는 항원성 단백질 고정화를 통한 돈단독 질병에 대한 백신 제조 방법에 대한 것이다.
