A method and apparatus to record and track patient's estimation of arbitrary factor types, to analyze response errors utilizing discrete measurements, to isolate errors in various factor types and their response correlations, to enable patient in refining factor mix to reduce estimated outcome variations, and to improve patient estimation with corrections using a continuous feedback system. The input factors for the treatment in case of a Diabetic patient may be food intake, medication, activity, stress level etc, while the treatment outcome or response may be blood glucose level that the patient needs to keep within specific limits. Present invention enables a chronic care patient, such as a Diabetic patient, to make better and informed decisions about their treatment, reduce input factor estimation errors, reduce outcome parameter variations, and improve the patient well being by better treatment control.