JOSEPH A. TINO,ANDREW J. TEBBEN,KHEHYONG NGU,JOHN E. MACOR,WEIWEI GUO,HUA GONG,MYRA BEAUDOIN BERTRAND,SALEEM AHMAD,DOUGLAS G. BATT,SCOTT HUNTER WATTERSON,QINGJIE LIU
申请号：
ARP150103454
公开号：
AR102426A1
申请日:
2015.10.23
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
The same is true for the use of these compounds as inhibitors of BTK thyroid hormone (quisasa) and pharmaceutical compounds containing these compounds. These compounds help to treat, prevent or slow down the spread of diseases or diseases in various fields of treatment, such as autoimmune diseases and vascular diseases. 1. Claim 1: a compound characterized by formula (1),a. A (I) is the rest of the formula group (2)；(ii) a remainder of the group of formulas (3)；(iii) a remainder of the group of formulas (4)；(IV) the rest of the formula group (5)；(v) The rest of the formula group (6)；(VI) - chr831222 (pirideni), where each pyridine is replaced by r8310y and r8313；Q¹ is -NR⁷Q²,-CR R NR Q-C (O) NR⁷ (C₁₋₄ alkyl substituted with zero or 1 R¹¹),-CH = CH₂,-CH 3DC (CN) S (O) CH-S (O) CH 3DCR R-483111 (zinc dichloride),-No. 8311 (quinazolin-4-ilo changed to 0 or 1 R1),3. Methylpyridine-2-no-1-ilo, or a periodic group selected from 1h-pirol-2 (5H) - on-1-ilo, isindolin-1-on-2-ilo, quinazolin-4 (3H) - on-3-ilo and quinazolin-2.4 (1H, 3H) - dion-3-ilo. Each periodic group is replaced by zero to two independent F, Cl, ch-832323 substitutes；-CN, and -OCH₃；Q2 es-cn, - C (o) (c831832424 replaced by zero or 1 R1),-C (o) (cycloquilo c83231； 8326 is replaced by zero or 1r1)；-C (o) (cycloquenilo c832531 and 832626)；-C (O) CR 3DCR R-C (O) C (R) 3DCHCH N (CH)-C (O) C CR-C (O) C C (hidroxialquilo C)-C (O) C ° C (phenyl),-C (O) C CSi (CH)o -S (O) CH 3DCHRR1 is h, ch832323,-CF8323,O replace phenyl with zero or 1.1 m2；R2 is h, ch832323,Cyclopropene, or phenyl, substituted with zero or 1 R2,1. Each time zero or one R 1 and R2 are replaced by zero or 1.1 km2；R3: H, F, Cl, I -, CN, o-ch8323；R8308es h, F, - Oh, - O (rent c832183314)-O (alquil C) -O- (alquilo C)-O (CH₂) ₁₋₃ (phenyl),-O (CH₂) ₁₋₃ (methoxyphenyl),o -O (CH) (morfolinilo)R es H F Cl o -CHR es H F Cl -CFor C₁₋₃ alkoxy；a. Each r8310； 74919, independent of H or F； r8311；at each occurrence, it is, independently, H, C₁₋₄ alkyl,or cyclopro
