INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) WIPO I PCT 0111111010 0111 °nolo mu IIIII Em OH oinio oimIE (10) International Publication Number WO 2018/165611 Al (51) International Patent Classification: CO7D 403/12 (2006.01) CO7D 401/12 (2006.01) CO7D 401/14 (2006.01) CO7D 405/04 (2006.01) A61K 31/404 (2006.01) C07D 209/42 (2006.01) C07D 401/04 (2006.01) A61P 31/04 (2006.01) (21) International Application Number: PCT/US2018/021848 (22) International Filing Date: 09 March 2018 (09.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/469,987 10 March 2017 (10.03.2017) US 62/523,154 21 June 2017 (21.06.2017) US (71) Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY [US/US]； Old Queens Building, Som- erset and George Streets, New Brunswick, New Jer- sey 08903 (US). TAXIS PHARMACEUTICALS, INC. [US/US]； 9 Deer Park Drive, Suite J-15, Monmouth Junc- tion, New Jersey 08852 (US). (72) Inventors； and (71) Applicants: LAVOIE, Edmond J. [US/US]； Old Queens Building, Somerset and George Streets, New Brunswick, New Jersey 08903 (US). PARHI, Ajit [US/US]； Old Queens Building, Somerset and George Streets, New Brunswick, New Jersey 08903 (US). YUAN, Yi [CN/US]； 9 Deer Park Drive, Suite J-15, Monmouth Junction, New Jersey 08852 (US). ZHANG, Yongzheng [US/US]； 9 Deer Park Drive, Suite J-15, Monmouth Junction, New Jersey 08852 (US). SUN, Yangsheng [US/US]； 9 Deer Park Drive, Suite J-15, Monmouth Junction, New Jersey 08852 (US). (74) Agent: MICKELSON, John W. et al.； 7851 Metro Park- way, Suite 325, Bloomington, Minnesota 55425 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI
