在腫瘤細胞中拮抗WNT信號傳遞的雙互補位多肽

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专利权人:

Boehringer Ingelheim International GmbH

发明人:

ZINZALLA, Vittoria,KUENKELE, Klaus-Peter,BUYSE, Marie-Ange,CROMIE, Karen,STAELENS, Stephanie,STRUBBE, Beatrijs

申请号：

HK18114876

公开号：

HK1255725A1

申请日:

2018.11.21

申请国别(地区):

HK

年份:

2019

代理人:

摘要：

The invention provides novel biparatopic LRP5/LRP6 cross-reactive binding polypeptides, and more specifically novel biparatopic LRP5/LRP6 cross-reactive immunoglobulin single variable domain constructs which can inhibit Wnt signaling pathways. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as cancer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/