您的位置: 首页 > 农业专利 > 详情页

EGFR-BINDING PEPTIDE
专利权人:
HOYA CORPORATION
发明人:
IIMORI, YUSUKE,YAMAGATA, MIZUE,SHIONO, TOSHITAKA
申请号:
EP13809117
公开号:
EP2865686A4
申请日:
2013.06.18
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
Provided are a substance capable of binding to EGFR specifically with a high affinity and a pharmaceutical agent containing the substance. Apeptide which contains at least an amino acid sequence represented by the formula (1), (2) or (3) and is composed of 12 to 50 amino acids: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒX 1 -His-X 2 -X 3 -Asp-X 4 -X 5 -X 6 -X 7 -X 8 -Trp-His€ƒ€ƒ€ƒ€ƒ€ƒ(1) (In formula (1), X 1 represents Trp or Phe X 2 represents Leu, Met, Ile or Val X 3 represents Ser, Ala, Thr, Gly, Asn, Asp, Glu, Arg or Lys X 4 represents Leu, Met, Ile, Val, Ala, Phe, Tyr, Trp, His or Cys X 5 represents Trp, Phe or Tyr X 6 represents Gln, Asn, Asp, Glu, Ala, Ser, Thr, Leu, Met, Lys or Arg X 7 represents Asn, Gln, Asp, Glu, Ser, Thr, Ala, Gly, Lys or Arg and X 8 represents Ala, Gly, Ser, Thr, Asn, Val or Cys) €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒPhe-His-Asp-Trp-X 11 -Pro-X 12 -X 13 -X 14 -X 15 -X 16 -X 17 €ƒ€ƒ€ƒ€ƒ€ƒ(2) (In formula (2), X 11 represents Leu, Met, Ile, Val, Ala, Phe, Tyr, Trp, His or Cys X 12 represents Glu, Asp, Gln, Asn, Ala, Ser, Thr, Lys, Arg or His X 3 represents Val, Ala, Leu, Ile, Met, Thr, Cys or Asn X 14 represents Ser, Ala, Thr, Gly, Asn, Asp, Glu, Arg or Lys X 5 represents Pro, Val, Ile, Lys, Ala, Met, Trp, Tyr, Ser, Thr, Cys or Phe X 16 represents Pro, Val, Ile, Lys, Ala, Met, Trp, Tyr, Ser, Thr, Cys or Phe and X 17 represents Asp, Glu, Asn, Gln, Ala, Ser, Thr, Lys, Arg or His) and €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒLeu-His-X 21 -Ser-X 22 -Trp-Met-X 23 -X 24 -X 25 -X 26 -X 27 €ƒ€ƒ€ƒ€ƒ€ƒ(3) (In formula (3), X 21 represents Gln, Asn, Asp, Glu, Ala, Ser, Thr, Leu, Met, Lys or Arg X 22 represents Glu, Asp, Gln, Asn, Ala, Ser, Thr, Lys, Arg or His X 23 represents Tyr, Phe, Trp, His, Leu, Met, Ile, Val, Cys or Ala X 24 represents Val, Ala, Leu, Ile, Met, Thr, Cys or Asn X 25 representsAsp, Glu, Asn, Gln, Ala, Ser, Thr, Lys, ArgorHis X 26 represents Ile, Val, Leu, Met, Ala, Phe, Tyr, Trp or Gly and X 27 represents His, Tyr, Phe, Lys, Arg, Leu, Met or Ala.)
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充