BORZACCHIELLO, Assunta,PAGLIUCA, Maurizio,SOLIMANDO, Nicola,NICOLAIS, Luigi
申请号：
IT201800007683
公开号：
IT201800007683A1
申请日:
2018.07.31
申请国别(地区):
IT
年份:
2020
代理人:
摘要：
The present invention relates to compositions based on: (a) a glycosaminoglycan or mixtures thereof；(b) one or more tocopherols, tocotrienols and mixtures thereof； (c) a selected stabilizer. The composition is in solution form, with the above agents being present within specific concentration ranges, without being engaged in formal chemical binding with each other. The component (a) can be e.g. hyaluronic acid (HA) or a salt thereof； the component (b) can be a polyether clathratee.g. a cyclodextrin, or a combination of a fatty acid with an emulsifier； the component (c) can be one or more among α- tocopherols, β-tocopherols, γ-tocopherols, δ-tocopherols； α-tocotrienols, β-tocotrienols, γ-tocotrienols, δ-tocotrienols； preferably the component (c) is vitamin E. In the present compositions, the above agents strongly cooperate to provide enhanced and more stable viscoelastic properties, resulting in a product with higher resistant to thermal treatments like e.g. heat-sterilization, autoclaving, etc. The present compositions, optionally loaded with pharmaceutically and/or cosmetically active agents, are advantageously used in medical or cosmetic methods.
