Austin L. GURNEY,Aaron Ken SATO,Christopher John BOND
申请号：
MX2014003558
公开号：
MX361712B
申请日:
2012.09.24
申请国别(地区):
MX
年份:
2018
代理人:
摘要：
The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.La presente invención se refiere a un anticuerpo biespecifico aislado laque específicamente se liga al VEGF y DLL4 humano. Un polinuecleótido iaslado caracterizado porque codifica un anticuerpo biespecífico que liga específicamente a VEGF humano y DLL4 humano. Una composición caracterizada porque comprende uno o más plinucleótidos que codifican un anticuerpo biespecífico que liga específicamente el VEGF y DLL4 humano.
