Teshome Mebatsion,Jules Maarten Minke,Frederic David
申请号：
US13767603
公开号：
US09567606B2
申请日:
2013.02.14
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides vectors that contain and co-express in vivo or in vitro immunogenic polypeptides or antigens together with an OX40L polypeptide, which functions as a genetic adjuvant. Together, the immunogenic polypeptide and the OX40L polypeptide elicit an immune response in animal or human, which is greater than the immune response elicited by the immunogenic polypeptide alone. In a particular example, the invention provides vectors encoding a Rabies G immunogenic polypeptide and a canine OX40L genetic adjuvant, which vectors elicit strong immune responses in canine against rabies virus.
