ANDREAS GRYCZKE,ANGELA OLF,BENEDIKT HARTWIG,CHRISTIAN MEIER,JUAN TOME ALCALDE,MELANIE LIEFKE,MICHAEL DAMM,MICHAEL GOTTSCHALK,NORBERT WINDHAB,ROSARIO LIZIO
申请号：
BR112012004967
公开号：
BR112012004967A2
申请日:
2010.08.30
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The invention relates to an oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles, wherein the dosage form has an at least two phase composition, wherein the phases can dissolve in the body after oral administration due to their formulation and the magnetizable particles are bound in formulation auxiliary substances and are present in a magnetized state, wherein the magnetized particles are present in at least two phases of the dosage form and generate magnetic fields, wherein these phases dissolve at different times in the body after oral administration, and wherein the magnetic field strength with respect to time, position and movement in the body is acquired using a detection system and can be evaluated using a computer-based evaluation system.
