Crystalline polymorph of 15B-hydroxy-osaterone acetate

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专利权人:

Ltd.;ASKA Pharmaceutical Co.

发明人:

Takayoshi Nakagawa,Hiroyuki Hayashi,Koichi Miyazaki,Shigeki Iwashita

申请号：

US16095782

公开号：

US10508130B2

申请日:

2017.05.10

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Provided is a crystalline polymorphic form A of 15β-hydroxy-osaterone acetate having an improved stability (storage stability, pulverization stability, and absorption characteristics). In a powder X-ray diffraction spectrum, characteristic diffraction peaks of the crystalline polymorphic form A of 15β-hydroxy-osaterone acetate appear at diffraction angles 2θ of 9.6°±0.2°, 17.1°±0.2°, and 20.2°±0.2°. The crystalline polymorphic form A has a melting point of 280 to 283° C. and is a prism crystal.

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