The Board of Regents of the University of Oklahoma
发明人:
Youngjae You,Sukyung Woo,Randle M. Gallucci
申请号：
US16810548
公开号：
US20200282034A1
申请日:
2020.03.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A method of treating or mitigating metastatic cancer in a subject having a primary tumor, by providing a prodrug system, the prodrug system comprising (1) a prodrug comprising at least one functional moiety and at least one linker linked to the at least one functional moiety, wherein the at least one functional moiety is inactive when linked to the linker, and wherein the at least one linker is cleavable by singlet oxygen, and (2) a sensitizer which when exposed to an activator results in generation of singlet oxygen by the sensitizer, causing cleavage of the at least one linker thereby activating the at least one functional moiety, wherein the sensitizer optionally is linked to the functional moiety via the at least one linker, administering the prodrug system to the subject, and exposing the primary tumor to the activator causing activation of the functional moiety and death of at least a portion of the primary tumor. Also disclosed is a method of making a whole-cell cancer vaccine, and using the vaccine to treat or mitigate metastatic cancer in a subject.
