Paolo G.V. MARTINI PGV,Madhusudan MATARAJAN M,Patrick Anthony John HASLETT PAJ,Albert Barnes SEYMOUR AB,‧馬丁尼,‧納塔拉詹,‧哈斯利特,‧西摩
申请号：
HK16109679.1
公开号：
HK1224174A
申请日:
2016.08.12
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
The present invention provides, among other things, bi-specific molecules including, but not limited to, antibodies, fynomers, aptamers, fuproteins, and protein binding domains that bind both CCL2 and LOXL2 and uses thereof, in particular, for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions. In some embodiments, the present invention further provides methods and compositions for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions based on the combination of mono-specific anti-CCL2 and anti-LOXL2 molecules.
