Provided is an antigen comprising a recombinant Respiratory Syncytial Virus (RSV) F protein, wherein the recombinant RSV F protein comprises an antigenic region flanked with a HRN region and a HRC region, and the antigenic region comprises one or more antigenic sites selected from the group consisting of site , site II, and site IV. The present disclosure also provides a nucleic acid molecule encoding the antigen and a vaccine composition comprising the antigen for eliciting immune response against RSV.提供包含重組呼吸道融合病毒(RSV)F蛋白的抗原，其中，該重組RSV F蛋白包含兩端與HRN區域和HRC區域相接的抗原性區域，該抗原性區域包含選自位點、位點II、和位點IV所組成群組的一個或多個抗原性位點。本揭露還提供編碼該抗原的核酸分子，以及包含該抗原的用於引起對抗RSV的免疫反應的疫苗組成物。
